Geometric singular perturbation theory in biological practice.

Singular Perturbation Theory in Output Feedback Control of Pure-Feedback Systems

This paper studies output feedback control of pure-feedback systems with immeasurable states and completely non-affine property. Since availability of all the states is usually impossible in the actual process, we assume that just the system output is measurable and the system states are not available. First, to estimate the immeasurable states a state observer is designed. Relatively fewer res...

Dynamical features of the MAPK cascade

The MAP kinase cascade is an important signal transduction system in molecular biology for which a lot of mathematical modelling has been done. This paper surveys what has been proved mathematically about the qualitative properties of solutions of the ordinary differential equations arising as models for this biological system. It focusses, in particular, on the issues of multistability and the...

Geometric Singular Perturbation Theory

Extending Geometric Singular Perturbation Theory to Nonhyperbolic Points - Fold and Canard Points in Two Dimensions

The geometric approach to singular perturbation problems is based on powerful methods from dynamical systems theory. These techniques have been very successful in the case of normally hyperbolic critical manifolds. However, at points where normal hyperbolicity fails, the well-developed geometric theory does not apply. We present a method based on blow-up techniques, which leads to a rigorous ge...

Spectral Stability of Small-Amplitude Traveling Waves via Geometric Singular Perturbation Theory

This thesis is concerned with the spectral stability of small-amplitude traveling waves in two different systems: First, in a system of reaction-diffusion equations where the reaction term undergoes a pitchfork bifurcation; second, in a strictly hyperbolic system of viscous conservation laws with a characteristic family that is not genuinely nonlinear. In either case, there exist families φε, ε...